Infectious Disease
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Cefiderocol (Fetroja)
Cefiderocol is a novel siderophore cephalosporin with a wide spectrum of activity against difficult-to-treat gram-negative organisms for which there currently are limited treatment options.
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Temperature Trajectories to Find Sepsis Subphenotypes
The authors of this study used development and validation cohorts to retrospectively identify temperature trajectories over the first 72 hours from presentation in the setting of sepsis. Patients presenting with hyperthermia that resolved quickly (within the first 24 hours) had lower mortality compared to those with slow resolution or those presenting with hypothermia.
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Candida auris Resistant to Azole Antifungals, Amphotericin B, and Echinocandins
Infection with Candida auris resistant to azole antifungals, amphotericin B, and echinocandins was identified in three patients in New York. Resistance to echinocandins was first detected after the patients had received an echinocandin as treatment.
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The Safety and Effectiveness of Pyrethroid Insecticides as the Battle Against Mosquitoes Continues
There is a statistical association between having a urine test suggestive of exposure to pyrethroid insecticides and increased mortality over the subsequent 14 years.
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Neuraminidase Inhibitors Reduce Hospital Length of Stay in Patients With Clinically Suspected or Laboratory-Confirmed Influenza A
A meta-analysis that included more than 18,000 patients from 70 clinical centers in 36 countries found that neuraminidase inhibitors started at the beginning of hospitalization in patients with clinically suspected or laboratory-confirmed influenza A reduced the length of hospitalization by 19%.
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Icosapent Ethyl Capsules (Vascepa)
Icosapent is the first drug approved to reduce the risk of cardiovascular events in patients with established cardiovascular disease and hypertriglyceridemia on maximally tolerated statin therapy.
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CNS Agents Emerge as Frontrunners in FDA-Approved Treatments for Low Libido in Women
Low libido is the most common sexual complaint, affecting up to 38.7% of women, with up to 12.3% also reporting significant distress associated with this condition. Debate continues about how female desire disorders are characterized, diagnosed, and treated.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Fever of Unknown Origin Due to Cat Scratch Disease
Disseminated cat scratch disease may present as a fever of unknown origin.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, Do Cause More Adverse Effects
Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.