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Infectious Disease Alert Updates

Meningitis Diagnostics

Anti-parasitic Therapy of Chronic Chagas’ Cardiomyopathy

Two thousand eight hundred fifty-four patients with Chagas’ cardiomyopathy were randomized to benznidazole or placebo, were treated for up to 80 days, and were followed for a mean of 5.4 years. Trypanocidal treatment with benznidazole reduced serum parasite detection but did not reduce clinical cardiac deterioration.

Oritavancin: Formulary Considerations

Oritavancin is a lipoglycopeptide bactericidal antibiotic for intravenous administration with activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus.

Acetaminophen for Fever in the ICU

Seven hundred ICU patients with fever and known or suspected infection were randomly assigned to receive acetaminophen 1 g IV or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. Early administration of acetaminophen did not affect number of ICU-free days.

Dual Combination ART with Cabotegravir and Rilpivirine Is Effective for Maintaining HIV Virological Suppression

Results of the phase 2 LATTE study show that after 24 weeks of induction triple therapy, maintenance therapy with cabotegravir (a long-acting dolutegravir analogue) and rilpivirine led to virological suppression in 82% of patients, compared to 71% who received efavirenz plus two NRTIs.

Cutaneous Leishmaniasis in Syrian Refugees

Cutaneous leishmaniasis is spreading as refugees move from Syria through Turkey into Europe and throughout the world. Aware clinicians can consider diagnostic testing when facing unusual skin lesions in refugees.