Infectious Disease Topics
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Oritavancin: Formulary Considerations
Oritavancin is a lipoglycopeptide bactericidal antibiotic for intravenous administration with activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus.
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Acetaminophen for Fever in the ICU
Seven hundred ICU patients with fever and known or suspected infection were randomly assigned to receive acetaminophen 1 g IV or placebo every 6 hours until ICU discharge, resolution of fever, cessation of antimicrobial therapy, or death. Early administration of acetaminophen did not affect number of ICU-free days.
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Dual Combination ART with Cabotegravir and Rilpivirine Is Effective for Maintaining HIV Virological Suppression
Results of the phase 2 LATTE study show that after 24 weeks of induction triple therapy, maintenance therapy with cabotegravir (a long-acting dolutegravir analogue) and rilpivirine led to virological suppression in 82% of patients, compared to 71% who received efavirenz plus two NRTIs.
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Cutaneous Leishmaniasis in Syrian Refugees
Cutaneous leishmaniasis is spreading as refugees move from Syria through Turkey into Europe and throughout the world. Aware clinicians can consider diagnostic testing when facing unusual skin lesions in refugees.
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Xenotourism: Live Cell Therapy, Maybe Not So Therapeutic
ABSTRACT & COMMENTARY: Beware injection with sheep fetal cells.
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Infectious Disease Alert Updates
Coccidioidomycosis: Is the “Zone” Growing?
Cocci as a Cause of Marine Mammal Mortality
Initial and Much Too Subtle Ebola Virus Infection
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Arboviral Infections in the United States — Not Just West Nile
West Nile virus accounted for 95% of arbovirus infections in 2013 reported to CDC, with the majority causing neuroinvasive disease.
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Treatment of Vertebral Osteomyelitis: A Brief Narrative Summary of the New IDSA Recommendations
A new IDSA guideline has recommendations providing best expert advice on management of native vertebral osteomyelitis.
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Clostridium difficile Infection — Back to the Future
This study provides strong evidence that the diagnosis of Clostridium difficile infection (as opposed to colonization) should be made on the basis of evidence of toxin production, not the mere presence of the organism as detected by glutamate dehydrogenase testing or the presence of toxin genes.
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Intestinal Fibrosis and Immune Reconstitution in Patients with HIV Infection
Duodenal biopsies in patients naïve to combination antiretroviral therapy (cART) underwent tissue staining and were examined. Intestinal myofibroblast activation was correlated with intestinal fibrotic changes and poor immune reconstitution following cART.