Infectious Disease Topics
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Cefpodoxime proxetil (Vantin®)
Cefpodoxime is an oral third-generation cephalosporin antibiotic that was FDA-approved in 1998 for the treatment of various mild to moderate susceptible infections.
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Diabetes and Vitamin C Deficiency May Be Common
Low levels of vitamin C were noted in seven of 11 patients with diabetes, including six of seven with lower extremity ulcers. Vitamin C repletion appeared to help heal these ulcers.
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Cryptosporidiosis in India — and in Your Community Swimming Pool?
Almost all children in some parts of India have at least one Cryptosporidium infection during the first three years of life.
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Antibiotic Stewardship in Outpatient Settings
The implementation of antibiotic stewardship principles in all outpatient settings is crucial to the struggle against growing antimicrobial resistance and to optimal patient outcomes.
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No Significant Association Between Autism Risk and Maternal Influenza and Vaccination
A very large cohort study over 11 years failed to find an association between autism risk and maternal influenza infection or influenza vaccination during pregnancy. A low risk of autism was associated on initial analysis with first-trimester vaccination, but adjusting statistically for the multiplicity of hypotheses tested in the study showed that this association could be due to chance (P = 0.10).
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Fecal Transplant vs. Oral Vancomycin Taper for Recurrent Clostridium difficile Infection
In a small randomized, controlled trial that compared fecal microbiota transplant (FMT) administered by enema to a six-week oral vancomycin taper, FMT was not more effective for patients with recurrent Clostridium difficile infection.
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Infectious Disease Alert Updates
Wee Bacterium Parasitizes Other Oral Bacteria; How Safe Is Your Honey?; Benefits of TB Screening Confirmed
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Can the Human Papillomavirus Vaccine Cure Cervical Dysplasia?
In this randomized, controlled trial, the HPV 16/18 vaccine did not hasten resolution of existing oncogenic HPV infections nor prevent persistent HPV 16/18 associated infection and cervical dysplasia recurrence after loop electrosurgical excisional procedure treatment.
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VRE and MRSA: Should We Stop Routine Contact Precautions?
The value of routine contact precautions for VRE and MRSA is strongly challenged.
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Empirical Antifungals in the ICU — Probably Not Helpful
Two hundred sixty non-neutropenic ICU patients with clinical evidence of sepsis receiving broad-spectrum antibiotics and known to be colonized by Candida species were randomized to micafungin for 14 days vs. placebo. Empirical micafungin therapy did not increase invasive fungal infection-free survival at 28 days.