Infectious Disease Topics
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Comparing Adjuvant Clindamycin to Linezolid for Invasive Group A Streptococcal Infections
In a retrospective, single-center cohort study of patients with severe group A streptococcal infection, there was no significant difference in clinical response in those treated with adjunctive clindamycin as compared with adjunctive linezolid
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Imported Gestational Malaria
Pregnant women can develop malaria in non-endemic areas, even when they are far removed from malaria exposure both geographically and temporally.
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ID Consultation Leads to Reduced Mortality from Gram-Negative Bacteremia
A multicenter, retrospective cohort study on patients with gram-negative bacteremia found infectious diseases consultation was associated with a 40% decrease in 30-day mortality.
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2024 Resolution: Not to Be Replaced by a Machine
Chatbots, such as ChatGPT, are thought to have potential to eventually replace some straightforward infectious disease consultations. However, current technology does not yet instill confidence that the use of chatbots will be adequately accurate or safe for complex patient care. In addition, philosophical and ethical constraints raise doubt about the value of replacing specialist physician consultations.
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Infectious Disease Alert Updates
Peak SARS-CoV-2 Viral Loads Delayed; Should MRSA Require Isolation and Contact Precautions?
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Sulbactam-Durlobactam for Treatment of Bacterial Pneumonia
Sulbactam-durlobactam is non-inferior to colistin in the treatment of serious bacterial infections caused by Acinetobacter baumannii-calcoaceticus complex organisms.
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Bartonella quintana in New York City
Six cases of Bartonella quintana infection were detected in New York City in individuals experiencing homelessness; four required cardiac valve replacement for endocarditis.
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Prevention of Ventilator-Associated Pneumonia
Administration of amikacin for three days beginning early in mechanically ventilated patients significantly reduces ventilator-associated pneumonia.
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Adjunctive Dexamethasone Is Not Beneficial for HIV Patients with Tuberculous Meningitis
A randomized, placebo-controlled clinical trial in human immunodeficiency virus-positive adults with tuberculous meningitis found no benefit for adjunctive dexamethasone in survival or risk of neurologic immune reconstitution inflammatory syndrome (IRIS). Side effects were similar to placebo.
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Comparing the Safety of Cefepime and Piperacillin-Tazobactam: The ACORN Trial
Qian and colleagues conducted a pragmatic, open-label, randomized clinical trial to determine whether the empiric use of piperacillin-tazobactam or cefepime affects the risk of acute kidney injury (AKI) or neurological dysfunction in patients hospitalized for sepsis. The study showed no significant difference in the incidence of AKI between groups, but rates of neurological dysfunction were slightly higher in patients treated with cefepime.