Infectious Disease Topics
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Oral Antibiotics Are Noninferior to Intravenous for Bone and Joint Infections
In a randomized, controlled trial of adult patients with bone or joint infections, researchers found oral antibiotic therapy was noninferior to intravenous therapy based on treatment failure at one year.
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Infectious Disease Alert Updates
Imagine: Multidrug-Resistant GC; A New Borrelia Species in the ‘Old World’
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Baloxavir Marboxil (Xofluza)
Baloxavir marboxil is a novel, oral, antiviral agent approved by the Food and Drug Administration (FDA) on Oct. 24, 2018, for the treatment of acute uncomplicated influenza in patients 12 years of age and older.
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Staphylococcus aureus on the Playground and in the Gym — Is It Inescapable?
Staphylococcus aureus, including methicillin-resistant S. aureus, is a frequent surface environmental contaminant on both children’s playgrounds and in adult fitness centers.
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Adenovirus and CNS Disease in Children
Forty-eight immunocompetent children with adenovirus-associated central nervous system disease were described. Thirty-eight percent of patients died or experienced permanent neurologic sequelae.
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Sleep Tight, Don’t Let the Mucorales Bite
Mucorales were found to commonly contaminate linen delivered to 15 transplant and cancer centers in the United States.
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The Slippery Slope of Inappropriate Antibiotic Use in Children
Inappropriate antibiotic use for a child with a viral respiratory infection is not a “one and done” error. Children who receive antibiotics when diagnosed with a viral respiratory infection are more likely to seek care for viral infections subsequently and to receive inappropriate antibiotics again.
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Probiotics Do Not Prevent C. difficile Infection in Hospitalized Patients
A retrospective cohort study from a single California hospital found the administration of probiotics to patients receiving antibiotics did not reduce the incidence of healthcare facility-onset Clostridioides difficile infection.
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Infectious Disease Alert Updates
Jump in Cocci Cases, Winter 2017; Who Knew the Ink Was Not Sterile? Homeless Population Requires Hepatitis A Vaccination
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IV to Oral Conversion of Antibiotic Therapy for Bacteremia Due to Enterobacteriaceae
Oral step-down antibiotic therapy (IV to oral conversion) is safe and effective in patients with bloodstream infection due to Enterobacteriaceae.