Infectious Disease Topics
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Measles — It’s Back!
The number of measles cases in the United States has exceeded 1,000 so far in 2019, the largest number in a quarter of a century.
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Infectious Disease Alert Updates
California Inmates With Cocci Lose Appeal; Tuberculosis Testing in Small Children
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Omadacycline (Nuzyra)
Omadacycline was approved in 2018 by the U.S. Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP).
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Histoplasmosis — Expansion of Risk Areas and Need for More Standardized Practice
Histoplasmosis is increasingly seen beyond the previous risk areas of the Ohio and Mississippi River valleys. Diagnostic and treatment practices vary widely.
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Vancomycin for MRSA Pneumonia Following Influenza in Children
Coinfection with methicillin-resistant Staphylococcus aureus (MRSA) in children with influenza is associated with high fatality. Data support the addition of a second anti-MRSA antibiotic to vancomycin in severely ill children.
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Is Fecal Microbiota Transplantation Superior to Fidaxomicin for Recurrent Clostridioides difficile Infection?
In a randomized clinical trial, researchers found the combination of oral vancomycin followed by fecal microbiota transplantation was superior to treatment with fidaxomicin or vancomycin alone for patients with recurrent Clostridioides difficile infection.
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Infectious Disease Alert Updates
Multi-Modal Interventions for Controlling CRE: Which Is Best? Antimicrobial Resistance Genes — in the Arctic; Updated PEP Guidelines for Hepatitis A Vaccine
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Staphylococcus aureus Bloodstream Infections in the United States
Although the rate of hospital-onset MRSA bacteremia has decreased since 2012, the rate of decrease has slowed. The National Action Plan goal of a 50% reduction by 2012 compared to 2015 seems out of reach.
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Corticosteroid Administration in Sepsis May Be Associated With Lower 28-Day Mortality
In this systematic review and meta-analysis of randomized, controlled trials comparing administration of corticosteroids with placebo or standard supportive care in sepsis, corticosteroids were associated with reduced 28-day mortality.
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When to Screen for and Treat Asymptomatic Bacteriuria
New guideline recommendations indicate that the only unequivocal indications for screening and treatment of asymptomatic bacteriuria are pregnancy and undergoing endoscopic urologic procedures associated with mucosal injury.