Infectious Disease Topics
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Fulminant Clostridioides difficile Infection: Hold the IV Metronidazole?
The combination of oral vancomycin and intravenous metronidazole is not superior to vancomycin alone in the treatment of fulminant infection due to Clostridioides difficile.
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What Is the Risk of Joint Prosthesis Infection Resulting From Bacteremia?
The risk of periprosthetic joint infection resulting from bacteremia depends on the organism.
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Preventing Readmissions and Optimizing Outcomes for Staphylococcus aureus Bacteremia: Still a Long Journey Ahead
Using a population-based database, investigators found that the rate of readmission within 30 days following hospitalization for S. aureus bacteremia was high (22%) and resulted in high cost to the healthcare system.
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Infectious Disease Alert Updates
Intestinal Yeast Revisited — With a New Angle; Preemptive Steroids for TB/HIV Treatment; Fluoroquinolone for Exposure to Drug-Resistant Tuberculosis
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Antimicrobial Susceptibility Testing in Cystic Fibrosis — An Unfortunate Failure
The results of antimicrobial susceptibility testing of respiratory isolates from patients with cystic fibrosis failed to predict outcomes of antibiotic therapy.
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Recurrent Clostridioides difficile Infection: Better Outcomes With Fecal Microbiota Transplantation Than With Antibiotics
Relative to vancomycin or metronidazole treatment of recurrent Clostridioides difficile infection, treatment with fecal microbiota transplantation is associated with a reduced risk of bloodstream infection, shorter hospital length of stay, and improved survival.
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Fatal Bacteremia Due to Fecal Microbiota Transplantation
Two patients developed bacteremia due to an extended-spectrum beta-lactamase producing Escherichia coli that had been transmitted to them via stool transplantation.
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Uninfected Children Exposed Prenatally to HIV Exhibit Language Delays
In South Africa, uninfected children exposed to human immunodeficiency virus (HIV) exhibit delays in receptive and expressive language at 24 months compared to non-HIV-exposed children.
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Colonization With Clostridioides difficile Frequently Leads to a Misdiagnosis of Healthcare-Associated Infection
A prospective cohort study from a single institution found 27% of patients diagnosed with healthcare-associated C. difficile infection were colonized with the same isolate on admission.
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Combination Therapy With Daptomycin Plus Beta-Lactam Antibiotics in MSSA Bacteremia
In a retrospective cohort study of 350 patients, the combination of a beta-lactam antibiotic plus daptomycin was not superior to beta-lactam monotherapy in patients with bacteremia due to methicillin-susceptible Staphylococcus aureus.