Infectious Disease Topics
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A New Treatment for Recurrent Bacterial Vaginosis?
In this randomized controlled trial of 228 women, Lactobacillus crispatus CTV-05 (Lactin-V) applied vaginally for 11 weeks reduced the incidence of recurrent bacterial vaginosis from 45% in the placebo arm to 30% in the Lactin-V arm.
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Rotavirus Vaccine Is Safe and Effective
Routine rotavirus vaccination of infants, when implemented broadly, is safe and is associated with reductions in diarrhea-related hospitalizations, mortality, and morbidity (such as malnutrition) in children.
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Outcomes with Daptomycin Plus a β-Lactam Compared to Daptomycin Alone for MRSA Bacteremia
In a retrospective cohort study, investigators found the addition of a β-lactam antibiotic to daptomycin led to less clinical failure (60-day all-cause mortality and/or 60-day recurrence) in patients with methicillin-resistant Staphylococcus aureus bacteremia.
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COVID-19 in Early Infancy
An evaluation of 18 infants with COVID-19 in the first three months of their lives found that the illness generally was not severe despite the presence of very high viral loads.
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COVID-19: Lessons from Spring Break
A high rate of COVID-19 occurred as the result of an outbreak in spring breakers. Rapid recognition and intervention, as well as the youth and good health of those infected, was effective in limiting the adverse consequences.
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Infectious Disease Alert Updates
Let’s Not Shake on This; The Tricky Business of Treating Early Cocci; On-Site Rapid Detection of Bacteriuria
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Ceftriaxone-Resistant Salmonella Typhi in the United States Associated with Travel to or from Pakistan and Iraq
Typhoid fever resulting from antibiotic-resistant strains is being imported from Pakistan and Iraq.
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IDSA Sepsis Committee and SEP-1 Quality Measures
The IDSA Sepsis Committee proposes that The Centers for Medicare & Medicaid Services’ Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) should be applied only to septic shock, not sepsis without shock.
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Contact Isolation Is Not Better than Standard Precautions for Decreasing Acquisition of ESBL-Producing Enterobacterales
In a multicenter, cluster-randomized crossover trial, researchers compared standard precautions vs. contact isolation for preventing acquisition of ESBL-producing Enterobacterales (ESBL-E) in non-intensive care unit settings. Contact isolation did not decrease the number of hospital-acquired ESBL-E cases, which questions the value of the practice.