Infectious Disease Topics
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Metformin Reduces SARS-CoV-2 Viral Load in Outpatients with COVID-19
A randomized, placebo-controlled clinical trial of outpatients with COVID-19 found that metformin reduced SARS-CoV-2 viral load 3.6-fold compared to placebo, while ivermectin and fluvoxamine showed no benefit.
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The Rise of Oropouche Virus
Oropouche virus is an arthropod-borne virus that has been primarily endemic to the Amazon region. The incidence of Oropouche virus disease has significantly increased over the past few years, and recent outbreaks have been reported in areas without previous endemic transmission and have led to fatalities and vertical transmission resulting in adverse pregnancy outcomes.
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Infectious Disease Alert Updates
Abandoning Universal COVID Admission Screening; Does Obesity Affect HIV Drug Levels? Eat Your Fruits and Vegetables!
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Out of Africa Again? A New Version of Mpox
A novel mpox clade has emerged in Africa and has the potential for a global epidemic.
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Effectiveness and Safety of Transitioning to Oral Antibiotics in Solid Organ Transplant Recipients with Uncomplicated Gram-Negative Bloodstream Infection
In a retrospective observational study, transitioning to oral antibiotics was demonstrated to be as effective and safer in solid organ transplant recipients with uncomplicated gram-negative bacteremia as compared with completion of therapy with intravenous antibiotics.
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Extensively Drug-Resistant Shigella on the Rise
The prevalence of Shigella resistant to azithromycin, ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, and ampicillin is increasing.
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Delusional Infestation
Delusional infestation, previously known as delusional parasitosis, is a condition with which patients believe that their bodies are infested with abnormal living organisms or non-living substances. Many patients can recover with a good therapeutic clinician-patient relationship and, usually, the use of risperidone, aripiprazole, or olanzapine.
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Mortality in Sepsis Patients Treated with Piperacillin-Tazobactam vs. Cefepime
A retrospective cohort study that included more than 7,000 patients with sepsis and no clear indication for anti-anaerobic coverage found receipt of piperacillin-tazobactam was associated with higher mortality and increased duration of organ dysfunction compared to cefepime.
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Infectious Disease Alert Updates
Pushing for STI Testing in Those at Risk; TB Screening Dismayingly Low in Those at Risk
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Varicella Zoster Meningitis — What Is the Optimal Therapy?
The authors concluded that their results indicate a need for controlled trials comparing intravenous acyclovir to valacyclovir or to no antivirals in the management of varicella zoster meningitis without neurological complications in immunocompetent patients.