Infectious Disease Topics
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Surge of HIV Patients Present to EDs, Leaders Call for Expanded Screening
Investigators discovered a more than twofold increase in cases of acute HIV during the COVID-19 pandemic as part of an ED-based screening program at UChicago Medicine. The cause of the increase remains unknown, but it underscores the importance of screening despite the fact the pandemic has strained all resources.
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EDs Administer Monoclonal Antibody Therapy to High-Risk COVID-19 Patients
Clinicians can use new monoclonal antibody therapies to treat high-risk patients presenting with mild to moderate COVID-19 symptoms. However, despite the promise to depress viral loads, logistical and other challenges continue to stand in the way of larger-scale use. Still, some EDs are trying the therapeutics, with promising results.
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COVID-19 Affected U.S. Life Expectancy: How Bad Is It?
The pandemic dinged the average, but the latest data do not tell the whole story.
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One Dose, Lower Temps May Suffice for Pfizer/BioNTech COVID-19 Vaccine
Encouraging new data emerge regarding storage, administration requirements.
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U.K. Approves First COVID-19 Human Challenge Trial
Volunteers will be infected with virus so researchers can learn more about pathology, speed effective vaccine development.
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Infectious Disease Alert Updates
Outcome of Coccidioidomycosis in the Pre-Antifungal Era; PET Imaging for Fever of Unknown Origin; High Rates of Thromboembolism in COVID-19
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Clinician Alert: XDR Salmonella Typhi Acquired in the United States
Nine patients in the United States with no travel history had typhoid fever due to extensively drug-resistant Salmonella Typhi.
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Ventricular Assist Device Infections: More Questions Than Answers?
Almost two-fifths of patients with left ventricular assist devices develop associated infections. The optimal appropriate management remains to be determined.
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Oral Moxifloxacin vs. Intravenous Ertapenem Followed by Oral Levofloxacin and Metronidazole for Acute Appendicitis
A randomized controlled clinical trial found that a seven-day course of oral moxifloxacin was not noninferior to two days of intravenous ertapenem followed by five days of levofloxacin and metronidazole in adults with uncomplicated acute appendicitis.
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Unexpected Pediatric Benefits of the COVID-19 Pandemic
Despite the global tragedy of the COVID-19 pandemic, clinical experience suggests that there also have been some favorable indirect effects of pandemic-induced lockdowns on pediatric health. Specifically, there are lower rates of unscheduled primary care visits, emergency department visits, and hospitalizations for medical problems – without an increase in incompletely managed serious diseases.