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A nationwide cohort study of adults in Denmark found that proton-pump inhibitor (PPI) use was associated with a moderately increased risk of community-associated Clostridioides difficile infection, and the risk remained elevated up to one year after PPI treatment had stopped.
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Primary amebic meningoencephalitis is a rarely diagnosed worldwide disease associated with exposure to fresh water that causes highly lethal, rapidly progressive central nervous system infection but may be treatable in some cases, necessitating maintenance of a high index of suspicion in appropriate cases.
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Fidaxomicin is preferred over vancomycin for both initial and recurrent cases. Bezlotoxumab is recommended in many cases of recurrent infection and initial infection in patients at high risk of recurrence.
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The occurrence of myocarditis after receipt of COVID-19 mRNA vaccines is most frequent in young males and generally is benign, with rapid resolution with only supportive care. Careful analysis indicates that the benefit of vaccination outweighs the risk in all groups for whom the vaccine is recommended — including young males.
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Multisystem inflammatory syndrome in children (MIS-C) can be a devastating post-COVID-19 complication, but treatment seems effective. High-dose steroids and intravenous immune globulin (IVIG) are commonly used, although new studies give conflicting findings as to whether it is best to use both treatments together.
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Sexual Distancing vs. Access to Care During COVID; Zoonosis in Federal Service Dogs; Echinococcus in Saskatchewan
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Chronic Q fever is a frequent and potentially lethal complication of acute infection that may first be diagnosed a decade afterward.
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A six-week course of antibiotic therapy was “not noninferior” to a 12-week course in patients with prosthetic joint infection, at least in those who had undergone debridement and implant retention.
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For children with acute vomiting (but not diarrhea), rapid rectal swab testing for bacterial and viral pathogens has potential for helping clinicians confirm a diagnosis of gastroenteritis and, thus, avoid unnecessary evaluation for other diagnoses.
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The diagnosis of malaria depends on detection of the parasite, but the spleen is where the money is.
