Infectious Disease Topics
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Pediatric Pneumonia — Diagnostic and Therapeutic Stewardship
A randomized, multicentered trial in the United Kingdom and Ireland showed children receiving amoxicillin for community-acquired pneumonia perform similarly well with lower dose (35-50 mg/kg/day vs. 75-90 mg/kg/day) and shorter duration (three vs. seven days) treatments.
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Surviving Sepsis 2021 Update
Some of the important changes include clearer differentiation of sepsis vs. septic shock and, for numerous recommendations, changing the strength and quality of evidence to support many.
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Infectious Disease Alert Updates
Pyrethroids losing activity against mosquitoes; Resistance erodes standard treatment for pneumonia; and homelessness and COVID-19.
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SARS-CoV-2 Rapid Antigen Testing in a Nursing Home Outbreak
Rapid antigen testing was accurate in detecting SARS-CoV-2 antigen when compared to polymerase chain reaction.
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Well-Appearing Febrile Infants: New Guidelines for Evaluation and Management
New guidelines provide specific recommendations for the use of diagnostic testing, antimicrobial treatment, and ongoing care based on age for children between 8 and 60 days of age.
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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Environmental Shedding of MRSA Is Far Greater than from Multidrug-Resistant Gram-Negative Bacilli
An observational cohort study revealed shedding of methicillin-resistant Staphylococcus aureus by colonized patients outside hospital rooms or during outpatient clinic visits occurred more often than in those colonized by multidrug-resistant gram-negative bacilli.
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Emerging Options for Malaria Prevention
New data suggest that combining vaccination with chemoprophylaxis is better than either intervention alone, and a small pilot study suggests that a monoclonal antibody infusion is effective in preventing malaria infections.
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Infectious Disease Alert Updates
Sepsis Bundle Erodes Gains in Stewardship; Asymptomatic Transmission of COVID-19 in Households; When Is Hand Hygiene Personally Protective? -
Quinacrine for Refractory Giardiasis
Quinacrine is highly effective in the treatment of giardiasis that is recalcitrant to initial therapy with other agents, but patients must be warned about neuropsychiatric effects.