Infectious Disease Topics
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.
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Ethical Justification for Research on Dangerous Pathogens
Recent inflammatory headlines suggested researchers had created a more dangerous version of COVID. However, those researchers said the headlines were misleading. Nevertheless, it spotlighted the ethical concerns involving research on pathogens.
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It’s Not All About the Cough
Be careful about relying on clinical queries that focus on the presence of cough for two or more weeks, which could lead to delays in the diagnosis of nearly half of pulmonary tuberculosis cases.
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WHO Lobbies for Updated Tuberculosis Vaccines
International organization says these investments could drive economic growth, improve health equity and antimicrobial stewardship, and lower mortality rates.
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Congress Issues Special Report on COVID-19 Pandemic
A select subcommittee exhaustively detailed what went wrong and offered suggestions on how to prevent future disasters.
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Evidence of Clinical Efficacy of Bebtelovimab in COVID-19
In a retrospective study, bebtelovimab demonstrated efficacy similar to Paxlovid in high-risk outpatients with recent onset of COVID-19 who reported mild to moderate symptoms.
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The Great Imitator Imitates Again
This case report serves as a reminder that even though pancolitis from secondary syphilis is rare, syphilitic proctitis is a not-uncommon manifestation of syphilis — and that syphilis can present as almost anything — even long COVID.
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Doxycycline Plus a Beta-Lactam to Treat Inpatients with Community-Acquired Pneumonia
In this retrospective study of an elderly male population hospitalized with community-acquired pneumonia, the combination of doxycycline with a beta-lactam was at least as effective as a respiratory fluoroquinolone or a combination of a beta-lactam with azithromycin.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.
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The Dental Procedure-Infective Endocarditis Link Controversy Continues
Infective endocarditis was more common with dental surgery or tooth extractions in the preceding four weeks in high-risk patients. Researchers abrogated this risk with antibiotic prophylaxis before the procedure.