Infectious Disease Topics
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Shortening the Duration of Tuberculosis Treatment
In patients with rifampin-susceptible tuberculosis, a planned eight-week regimen of bedaquiline plus linezolid together with isoniazid, ethambutol, and pyrazinamide, combined with a careful follow-on strategy, was non-inferior to a standard six-month regimen.
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Adjunctive Corticosteroids in Patients with Severe Community-Acquired Pneumonia
A double-blind, randomized, controlled trial conducted at 31 French medical centers demonstrated adult patients with severe community-acquired pneumonia who were given hydrocortisone had a lower risk of death by day 28 compared with those who received placebo.
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Doxycycline Demonstrates Protection Against Sexually Transmitted Infections
Common antibiotic could be a key tool to help stem the rising tide of reported cases.
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COVID Transmission During Air Travel
Despite careful air filtration in flying aircraft, there remains some risk of disease transmission during travel.
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Does COVID Vaccination Prevent Car Crashes?
In a large study, lack of COVID vaccination was associated with more incidents of car crash injuries.
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CDC: Candida auris Spreading at ‘Alarming’ Rate
The agency reported the number of clinical cases has risen each year since 2016, with the worst spike occurring during the 2020-2021 period.
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The Role of Influenza Vaccination in Cardiovascular Event Prevention
Researchers studied English patients with an acute cardiovascular event who received an influenza vaccine in the same 12-month period and compared that to the 120-day period after vaccination and the rest of the year. They observed those vaccinated were less likely to experience an acute cardiovascular event for 120 days after vaccine vs. the rest of the year.
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Infectious Disease Alert Updates
How to Assess CLABSI in Outpatient Infusion Therapy; Does Wearing Glasses Reduce the Risk of SARS-CoV-2 Infection?
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Form Follows Function — Structure-Based Vaccines Make Progress Against RSV
In older patients who are at risk for severe disease caused by respiratory syncytial virus (RSV), two new distinct vaccine candidates based on the stabilized prefusion F protein demonstrated efficacy and prevented RSV lower respiratory tract disease in patients older than age 60 years.
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Immortal Time Bias and Mortality Effects of 18F-FDG-PET/CT in Patients with Staphylococcus aureus Bacteremia
Staphylococcus aureus bacteremia is associated with high mortality and often is complicated by metastatic sites of infection that can be difficult to identify and control. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography has shown promise in some observational studies as an important diagnostic modality for detecting foci of infection and potentially guiding clinical management in ways that may lead to improved outcomes, including lower mortality. The validity of these findings has been questioned, however, due to the risk of significant bias.