Infectious Disease General
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Infectious Disease Alert Updates
Occupational Mpox in Healthcare Workers; Homeless People at Risk for Mpox; PRIORIX Is Interchangeable with MMRII
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COVID Transmission During Air Travel
Despite careful air filtration in flying aircraft, there still is some risk of disease transmission during flights.
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Golden State: Disseminated Gonococcal Infection
The diagnosis of disseminated gonococcal infection often is delayed, but the infection can most often be readily treated with ceftriaxone. Patients often lack urogenital symptoms.
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Dual Therapy Using Doxycycline and Azithromycin Is Superior to Monotherapy for Treating Severe Scrub Typhus
A multicenter, randomized, double-blind, controlled trial from India found dual therapy with intravenous doxycycline and azithromycin is more effective than either agent alone for treating severe scrub typhus.
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Highlights of Updated 2023 Pediatric Vaccination Schedules in the United States
In February, the annually updated immunization schedule for children in the United States was released by several professional organizations. Key updates involve the inclusion of the PCV-15 vaccine and COVID vaccines, as well as new comments about other vaccines.
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Immortal Time Bias and Mortality Effects of 18F-FDG-PET/CT in Patients with Staphylococcus aureus Bacteremia
Staphylococcus aureus bacteremia is associated with high mortality and often is complicated by metastatic sites of infection that can be difficult to identify and control. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography has shown promise in some observational studies as an important diagnostic modality for detecting foci of infection and potentially guiding clinical management in ways that may lead to improved outcomes, including lower mortality. The validity of these findings has been questioned, however, due to the risk of significant bias.
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Form Follows Function — Structure-Based Vaccines Make Progress Against RSV
In older patients who are at risk for severe disease caused by respiratory syncytial virus (RSV), two new distinct vaccine candidates based on the stabilized prefusion F protein demonstrated efficacy and prevented RSV lower respiratory tract disease in patients older than age 60 years.
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Infectious Disease Alert Updates
How to Assess CLABSI in Outpatient Infusion Therapy; Does Wearing Glasses Reduce the Risk of SARS-CoV-2 Infection?
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A Rapid Molecular Test Improves Time to Appropriate Therapy and Mortality in Patients with CRE Bacteremia
A multicenter observational study of patients with carbapenem-resistant Enterobacterales bacteremia found that time to receipt of active antibiotic therapy and mortality were improved in those whose blood cultures underwent rapid molecular testing for the Klebsiella pneumoniae carbapenemase gene. The mortality rate was 10% with ceftazidime-avibactam compared to 31% with polymyxin monotherapy.
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Nationwide Outbreak of Extensively Drug-Resistant Pseudomonas aeruginosa Infections from Contaminated Eye Drops
An outbreak of extensively drug-resistant Pseudomonas aeruginosa infection has been traced to use of contaminated artificial tears.