Infectious Disease General
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Infectious Disease Alert Updates
Abandoning Universal COVID Admission Screening; Does Obesity Affect HIV Drug Levels? Eat Your Fruits and Vegetables!
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Out of Africa Again? A New Version of Mpox
A novel mpox clade has emerged in Africa and has the potential for a global epidemic.
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Effectiveness and Safety of Transitioning to Oral Antibiotics in Solid Organ Transplant Recipients with Uncomplicated Gram-Negative Bloodstream Infection
In a retrospective observational study, transitioning to oral antibiotics was demonstrated to be as effective and safer in solid organ transplant recipients with uncomplicated gram-negative bacteremia as compared with completion of therapy with intravenous antibiotics.
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Extensively Drug-Resistant Shigella on the Rise
The prevalence of Shigella resistant to azithromycin, ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, and ampicillin is increasing.
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Delusional Infestation
Delusional infestation, previously known as delusional parasitosis, is a condition with which patients believe that their bodies are infested with abnormal living organisms or non-living substances. Many patients can recover with a good therapeutic clinician-patient relationship and, usually, the use of risperidone, aripiprazole, or olanzapine.
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Mortality in Sepsis Patients Treated with Piperacillin-Tazobactam vs. Cefepime
A retrospective cohort study that included more than 7,000 patients with sepsis and no clear indication for anti-anaerobic coverage found receipt of piperacillin-tazobactam was associated with higher mortality and increased duration of organ dysfunction compared to cefepime.
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Infectious Disease Alert Updates
Pushing for STI Testing in Those at Risk; TB Screening Dismayingly Low in Those at Risk
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Varicella Zoster Meningitis — What Is the Optimal Therapy?
The authors concluded that their results indicate a need for controlled trials comparing intravenous acyclovir to valacyclovir or to no antivirals in the management of varicella zoster meningitis without neurological complications in immunocompetent patients.
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Dengue Is Surging, Including in the Americas
Dengue is surging, and cases have been acquired in the United States, including in Puerto Rico and Florida.
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Beta-Lactam Antibiotics Administered via Prolonged Infusions Lead to Lower Mortality Risk Compared to Intermittent Infusions
In a systematic review and meta-analysis, the administration of beta-lactam antibiotics by prolonged infusions was associated with a significantly reduced risk of mortality at 90 days for critically ill patients with sepsis or septic shock as compared with intermittent infusions.