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Patients eligible for EFV-based haart (EFV plus two nucleoside RT inhibitors) were randomized to EFV in an escalating dose over two weeks vs. standard 600 mg/d dosing. NPAEs and sleep quality were assessed by questionnaires over the first 30 days of therapy.
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A population-based telephone survey was conducted among residents < 20 years of age in Antelope Valley, CA, from 2000 through 2006. During this period, 459 evaluable cases of herpes zoster among persons < 20 years of age were reported.
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In this issue: Clopidogrel and proton pump inhibitors; adverse events with tamsulosin after cataract surgery; new guidelines for persistent pain in the elderly; and FDA Actions.
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This investigation began when a young 29-year-old Taro farmer from one of the Micronesian islands, Satowan (population 650), presented to an indigent care clinic in Portland, OR, with an 18-year history of progressive plaque-like verrucas covering his lower extremities.
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Hochedz et al from Paris, France, described 60 adult travelers diagnosed with skin and soft-tissue infections (SSTI) seen between January 1, 2006 and August 30, 2007.
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A cluster of febrile respiratory illness (FRI) associated with ad14 was reported at Lackland AFB, Texas in 2007. Combined surveillance and retrospective cohort investigation identified 1,147 basic military trainees with FRI; 551 (48%) were infected with Ad14. Of those, 23 were hospitalized with pneumonia, four required ICU admission, and one died.
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In the first study, patients with Hepatitis C Virus (HCV) genotype 1 infection were randomized to one of four treatment groups: pegylated interferon (pIFN) + ribavirin (RBV) given for 48 weeks + TPV placebo given for 12 weeks (PR48) or pIFN+RBV given for 12 weeks + telaprevir (TPV) given for 12 weeks (T12PR12) or pIFN+RBV for 24 weeks + TPV 12 weeks (T12P24) or pIFN + RBV for 48 weeks + TPV 12 weeks (T12P48).
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Approximately 10% of international travelers are children (classified as those 18 years of age or younger in this study). As we note that more children are traveling, the number of malaria cases in travelers also is increasing.
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In a series of elegant experiments, kohanski et al demonstrated that the three major classes of bactericidal antibiotics, regardless of drug-target interaction, stimulate hydroxyl radical formation in bacteria.