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This study from a single diabetic foot clinic in France involved a retrospective chart review of patients who underwent surgical percutaneous bone biopsy with culture for microbiologic diagnosis of osteomyelitis. Patients included for study were those who had not received either local or systemic antibiotics for at least 4 weeks prior to cultures being obtained.
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Since the fda approval of moxifloxacin in December 1991 for the treatment of community-acquired pneumonia, sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated skin/skin structure infections, its indications for use has been expanded to include the treatment of complicated skin/skin structure infections and complicated intra-abdominal infections.
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The first article reports the results of an industry-sponsored clinical trial comparing TDF/ABC/3TC vs EFV/ABC/3TC in treatment-naïve patients. Three hundred forty patients were randomized. Baseline characteristics, including CD4 count and HIV RNA level were similar between the arms.
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Do Antidepressants Increase Risk of Suicide?; Can Viagra Improve Heart Function?; A Dramatic Increase of Clostridium difficile; FDA Actions
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The Clinton Foundation announced the successful conclusion of negotiations with several pharmaceutical companies to provide lower cost HIV testing and treatment to poorer countries. Four companies3 from India and 1 from South Africa have agreed to provide nevirapine and abacavir (at $USD 240 and $447 per patient per year, respectively), provided that certain conditions are met on an ongoing basis.
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Beginning in 1995, a remarkably extensive blood culture protocol was established at Stanford University Hospital for use in patients with fever of unknown origin or suspected endocarditis. This included the use of an average of almost 90 mL of blood from patients obtained by several venipunctures.
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Linezolid is an oxazolidinone antibiotic which has proven to be very useful in the treatment of Gram positive bacterial infections, including methicillin-resistant S. aureus (MRSA).
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The California Influenza Strain (A/California/07/2004 [H3N2]), first isolated in our own backyard in Santa Clara County, included in the 2005-2006 trivalent influenza vaccine, has been given the boot!
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This study ran from November 2000 to May 2002, recruited 611 patients from 58 centers predominantly from Europe, and set out to compare the efficacy and safety of these drugs for treating febrile, neutropenic patients with cancer and either proven or suspected infection due to Gram-positive bacteria in a prospective, blinded randomized controlled trial.