Infectious Disease Alert
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Need a Pig Heart? Beware Porcine Cytomegalovirus
The first recipient of a transplanted pig heart died with evidence of infection with a porcine cytomegalovirus.
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Human Papillomavirus Infections: We Need to Improve Vaccination Rates
The prevalence of human papillomavirus infections and their sequelae remain high, although this is a problem that is preventable with available vaccines.
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HPV Vaccination in Adolescence Prevents Cancer More than 10 Years Later
The authors of this long-term follow-up study of three cluster-randomized trials of human papillomavirus (HPV) vaccination evaluated cancer protection over up to 11 years of follow-up. During this time, 17 HPV-positive cancers were identified in the unvaccinated group, and zero were identified in the vaccinated group, indicating 100% vaccine efficacy at preventing HPV-associated cancers.
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COVID-19 Pre-Exposure Prophylaxis
The combination of tixagevimab and cilgavimab (Evusheld) was demonstrated to be effective in the prevention of symptomatic COVID-19, but much remains to be learned as SARS-CoV-2 continues to evolve.
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Updated Management of Malaria
Malaria is preventable and treatable, yet there still are hundreds of millions of cases of malaria each year. New guidelines encourage personal and community prevention. Treatment usually is with artemisinin-based combination therapy.
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Who Can Get the Janssen/J&J (Non-mRNA) COVID-19 Vaccine Now?
The Food and Drug Administration recently limited the use of the Janssen COVID-19 vaccine.
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Oral Tebipenem: A New Antibiotic for Multidrug-Resistant, Gram-Negative Complicated Urinary Tract Infections
A randomized clinical trial that compared oral tebipenem with intravenous ertapenem in patients with complicated urinary tract infection or acute pyelonephritis found tebipenem to be noninferior in efficacy. The safety profile was similar between the two drugs.
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International Outbreak of Acute Hepatitis in Children — Putative Role of Adenovirus 41
Cases of acute hepatitis in children, tentatively ascribed to adenovirus 41 infection, while first reported from a single hospital in Alabama, are being seen internationally.
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Infectious Disease Alert Updates
Recovering from Critical COVID; Oral and Anal Transmission of Syphilis
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A Case of Monkeypox in a Returned Traveler
The arrival of a traveler from Nigeria to the United States with monkeypox infection, which was quickly recognized, led to a massive public health response investigating exposed individuals, but no secondary cases were detected.