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Breast Cancer and the Use of Statins; Warnings Issued for IBS Drugs; FDA Actions
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History and Goals of Antiretroviral Therapy; Clinical Trials: Recent Assessments of Various Triple Nucleoside Regimens as HAART for Treatment-Naïve HIV-Infected Patients; Lower Efficacy With Stavudine, Didanosine, and ABC Triple NRTI Regimen; Tenofovir DF (TDF)/ABC/3TC Versus EFV/ABC/3TC in Antiretroviral-naïve HIV Patients; Atlantic Study: An Assessment of d4T/ddI/3TC; CLASS: Triple NRTI d4T/3TC/ZDV Versus NNRTI- and PI-based HAART; Efficacy From Trials With Quadruple PI-Sparing Therapy
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Interferon a-n1 (Wellferon), interferon a-n3 (Alferon), and interferon b-1b (Betaferon) were each found to have in vitro activity against a strain of the SARS coronavirus.
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Melioidosis is endemic in parts of Australia that may be visited by tourists. Allen Cheng reported that, as of March 20, 15 patients with melioidosis had been seen at the Royal Darwin Hospital during the 2003-2004 rainy season. The Royal Darwin is the referral center for the Top End region of the Northern Territory of Australia.
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Aspirin possesses potent activity against the formation of biofilms formed by Candida albicans and could be useful in combination for managing biofilm-associated infections.
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Erythromycin use is associated with a 2-fold increased risk of sudden cardiac death and a 5-fold increase in those who concurrently receive other medications that significantly inhibit its metabolism by CYP3A4.
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Rifaximin (Xifaxan) has rreceived US FDA approval on May 25, 2004, for the treatment of travelers diarrhea caused by enteropathogenic (non-invasive) Eschericiha coli in individuals at least 12 years of age. Rifaximin is a rifamycin that is poorly absorbed (< 0.4%) from the gastrointestinal tract, and thus achieves very high concentrations in the feces.
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Isolated pulmonic valve endocarditis is the topic of an interesting article from the Cleveland Department of Veterans Affairs Medical Center. Hamza and colleagues reported 3 of their own cases, involving men ages 47, 64, and 76, none of whom were intravenous drug addicts (IVDA). In 2 of the patients, Enterococcus faecalis was the causative pathogen, and in the other patient, a coagulase-negative staphylococcus was the pathogen.