Infectious Disease Alert
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SARS-CoV-2 Rapid Antigen Testing in a Nursing Home Outbreak
Rapid antigen testing was accurate in detecting SARS-CoV-2 antigen when compared to polymerase chain reaction.
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Well-Appearing Febrile Infants: New Guidelines for Evaluation and Management
New guidelines provide specific recommendations for the use of diagnostic testing, antimicrobial treatment, and ongoing care based on age for children between 8 and 60 days of age.
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Adjuvanted Zoster Vaccine: Persistent Protection
The adjuvanted recombinant zoster vaccine efficacy is high and persistent, with apparent plateauing at > 84% four to six years after vaccination.
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Environmental Shedding of MRSA Is Far Greater than from Multidrug-Resistant Gram-Negative Bacilli
An observational cohort study revealed shedding of methicillin-resistant Staphylococcus aureus by colonized patients outside hospital rooms or during outpatient clinic visits occurred more often than in those colonized by multidrug-resistant gram-negative bacilli.
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Emerging Options for Malaria Prevention
New data suggest that combining vaccination with chemoprophylaxis is better than either intervention alone, and a small pilot study suggests that a monoclonal antibody infusion is effective in preventing malaria infections.
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Infectious Disease Alert Updates
California mandates COVID-19 vaccine for healthcare workers; Seasonal coronavirus in stem cell transplant
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Adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Does Not Lead to Improved Clinical Outcomes
A longitudinal study from a single healthcare system found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle resulted in some changes in process measures, but did not lead to improvements in clinical outcomes.
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Treatment of Presumed Urinary Tract Infection in Afebrile Males: How Long Is Long Enough?
Symptom resolution after seven days of antibiotic therapy in afebrile males with presumed urinary tract infection was not inferior to 14 days of therapy.
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COVID-19: Effective Post-Exposure Prophylaxis
Subcutaneous administration of a combination of anti-SARS-COV-2 antibodies effectively prevented COVID-19 in most household contacts of cases.
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Updated Sexually Transmitted Infection Guidelines
The Centers for Disease Control and Prevention has updated their recommendations for the treatment of several sexually transmitted infections, including gonorrhea, trichomoniasis, bacterial vaginosis, pelvic inflammatory disease, and those due to Chlamydia trachomatis and Mycoplasma genitalium.