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During my final year of interventional cardiology training, a woman in her 60s was brought emergently to the cath lab in cardiogenic shock, with diffuse ST-segment elevations. She had undergone PCI of the LAD and RCA just over a week earlier at an outside hospital.
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The advent of highly sensitive troponin assays has shown detectable levels in apparently healthy subjects. Persistently elevated levels (> 99% percentile) can be observed in patients with a variety of chronic diseases, including coronary artery disease (CAD), making the accurate diagnosis of myocardial infarction (MI) challenging.
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This study, the Multicenter Automatic Defibrillator Implantation Trial Reduce Inappropriate Therapy (MADIT-RIT), was designed to test the hypothesis that programming implantable cardioverter-defibrillator (ICD) therapies with higher detection rates or delayed detection before initiation of therapy would decrease inappropriate shocks in ICD patients.
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Zolpidem and risk of falls; AVR and anticoagulation; statins in cancer patients; and FDA actions.
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As our population ages and outcomes from revascularization also improve, more elderly patients are being referred for coronary artery bypass graft surgery (CABG) and for percutaneous coronary intervention (PCI).
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Angioedema is an infrequent, but serious, adverse event from drug therapy. Drugs that affect the renin-angiotensin-aldosterone system have been linked to angioedema, but the relative frequency of this complication with these drugs is poorly understood.
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This paper details the result of a population-based cohort study of all Ontario, Canada, residents older than 66 years of age who began warfarin therapy for atrial fibrillation over an 11-year period.