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Implementation of an evidence-based extubation-readiness bundle was associated with a decrease in mechanical ventilation days and pneumonia in brain-injured patients.
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A systematic review and meta-analysis found that the healthcare-associated pneumonia concept was based on low-quality evidence confounded by publication bias and does not accurately identify antibiotic-resistant pathogens.
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Effective cardiopulmonary resuscitation (CPR) is partly dependent on the adequacy of manual chest compressions, but they are limited by interruptions and less than ideal conditions such as during transport. Mechanical chest compression devices have been developed that improve organ perfusion vs manual compressions in experimental studies, but there is little evidence of their clinical effectiveness and safety compared to manual compressions.
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Patients with chronic kidney disease, acute myocardial infarction and atrial fibrillation and treated with warfarin had a lower risk for death, MI and ischemic stroke without a higher risk of bleeding.
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In a prospective, open-label, intervention study conducted over four influenza seasons, higher dose oseltamivir compared to standard dose produced no additional benefits in patients with influenza A infection. It did lead to improved virologic response in those with influenza B, but this did not reach statistical significance.
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Resolution of Clostridium difficile-associated diarrhea in patients with cancer treated with fidaxomicin or vancomycin.
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The number of hospitalists in the United States has grown rapidly and it has been estimated that more than 80% of hospitals now employ hospitalists.
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Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomized trials.
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Administrative databases may not give an accurate representation of hospital-acquired pressure ulcer rates and may be inappropriate for use to compare hospitals and determine financial penalties.