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In a matched, retrospective cohort study, early use of daptomycin compared to vancomycin in MRSA bacteremia with vancomycin MICs > 1 µg/mL resulted in improved clinical outcomes, including less clinical failure at 30 days, lower mortality and less persistent bacteremia.
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Despite better compliance with hand hygiene and screening, use of isolation, and other techniques, ICUs remain notorious breeding grounds for hospital-acquired infections. A universal decolonization strategy reduces the total number of ICU bloodborne infections.
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Beta-blockers and noncardiac surgery; prenatal medication exposure and risk of autism; reasons for statin discontinuations; and FDA actions.
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As a federal program rolls out to award providers with incentives for achieving meaningful use in electronic health records, wide measure-by-measure variation can jeopardize the validity of electronic reporting.
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A nonrandomized, observational, comparative multicenter cohort study was conducted at 17 European medical centers. Patients treated with ampicillin+ceftriaxone (AC) were generally more ill at baseline than patients treated with ampicillin+gentamicin (AG).
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Bacteria were present on the cell phones of all hospital clinicians studied, with potentially pathogenic microorganisms isolated from 29% of them. Contamination with pathogens was found more commonly with smart phones than with non-smart phones, and by multivariable analysis no other factor was associated with this difference.
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The Get with the Guidelines-Resuscitation registry is a large, prospective registry of in-hospital cardiac arrests that analyzes data to promote quality improvement. In this paper, Chan and colleagues report the long-term outcomes in Medicare-age patients who suffered an in-hospital cardiac arrest and survived to discharge.
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Following an index episode of recurrent cellulitis, penicillin decreased the rate of recurrent leg cellulitis during a 12-month prophylactic period as compared with placebo, but this effect was not observed to be sustained.
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