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Zolpidem and risk of falls; AVR and anticoagulation; statins in cancer patients; and FDA actions.
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In this single-center, prospective study, median duration of antibiotics for community-acquired pneumonia (CAP) decreased from 10 to 7 days with an antibiotic stewardship program that included education and prospective feedback to the managing team.
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The use of non-steroidal anti-inflammatory drugs (NSAIDs) early after myocardial infarction (MI) has been shown to increase the risk of death or recurrent MI, but little is known about the long-term risks. Thus, this group from Denmark evaluated their national database and identified more than 99,000 patients who survived 30 days after discharge following their first MI.
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This study reports data from the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) on the clinical characteristics of infective endocarditis related to pacemakers and ICDs. ICE-PCS collected data on 3284 patients with endocarditis from 64 centers in 28 countries in a central database.
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Linezolid was non-inferior to vancomycin in patients with nosocomially acquired MRSA pneumonia. Although mortality was similar among linezolid- and vancomycin-treated patients, several outcomes (such as clinical cure and microbiological cure) favored linezolid.
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Institution of a formal audit and feedback program resulted in a decrease in use of broad-spectrum antibiotics and a 31% reduction in cases of Clostridium difficile infection.
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This comprehensive review on postoperative patient handoffs confirms that they are high-risk events associated with adverse patient outcomes, and permits the identification of several strategies likely to improve the process despite the incompleteness and other limitations of the existing literature.
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This study of 537 hospitals found that those with the lowest mortality rates for acute myocardial infarction have management strategies that differ in important ways from those at hospitals with higher acute myocardial infarction mortality.
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In a retrospective, propensity-score-matched, case-control study, investigators compared clinical outcomes and drug tolerabilities between nafcillin and cefazolin in the treatment of MSSA bacteremia. The authors found that cefazolin was as efficacious as nafcillin in the treatment of MSSA bacteremia while causing fewer adverse drug events.
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Knowledge of pediatric-specific antimicrobial susceptibility data improves prescribing selections of empiric antibiotic treatment. Providers should advocate for availability of pediatric-specific antimicrobial susceptibility data wherever practical.
