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Side effects of finasteride; new ruling on pharmaceutical companies paying generic manufacturers; and FDA actions.
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The recently published IST-3 trial has stimulated great interest in the expanded use of intravenous thrombolysis (IV rtPA). Wardlaw and colleagues assessed all of the evidence from published randomized trials for IV rtPA in acute ischemic stroke using a meta-analysis.
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Patients with diabetes mellitus (DM) are at increased risk of developing acute coronary syndromes (ACS). Furthermore, after hospitalization with ACS, patients with DM are at increased risk of suffering repeat hospitalization for ACS.
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Patients presenting to the emergency department (ED) with chest pain are often admitted to "rule out" myocardial infarction (MI). Many of the patients are subsequently found to have noncardiac causes of chest pain.
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Early cessation of prehospital seizures via an intramuscular injection of midazolam was at least noninferior, if not superior, to traditional intravenous lorazepam.
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A significant risk factor for ICU readmission is the illness severity (acute physiology score) associated with persistent physiological abnormalities at ICU discharge, regardless of initial ICU admission illness severity.
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When fewer ICU beds were available, patients experiencing a medical emergency team call were less likely to be admitted to the ICU and more likely to have their goals of care changed.
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Some patients who experience stroke or transient ischemic attack (TIA) of unknown cause (i.e., cryptogenic) are subsequently found to have a patent foramen ovale (PFO).
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A historical cohort study from San Francisco General Hospital evaluated patients ≥18 years old that were hospitalized and received at least one dose of ceftriaxone. In a multivariable analysis, for every day a patient also received doxycycline the rate of Clostridium difficile infection was 27% lower than for those who did not receive doxycycline (hazard ratio, 0.73%; 95% confidence interval, 0.56-0.96).
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Small subcortical brain infarcts, known as lacunar strokes, account for about 25% of all ischemic strokes.
