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A meta-analysis of 10 studies of heparin used either for prophylaxis or for treatment suggests that venous thromboembolism related to heparin-induced thrombocytopenia occurs frequently in patients previously treated with unfractionated heparin, but uncommonly in those on low molecular weight heparin.
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Among adults diagnosed with heart failure who had no prior statin use, incident statin use was independently associated with lower risks of death and hospitalization among patients with or without coronary heart disease.
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RFA should be considered a first-line therapy even after the first episode of symptomatic AFL. There is a better long-term success rate, the same risk of subsequent AF, and fewer secondary effects.
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Given its lack of benefit, possible harms, and expense, magnesium sulfate should not be used for tocolysis.
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Clostridium difficile diarrhea and colitis have now emerged as common nosocomial infections in hospitals throughout the developed world. Alarmingly, recent epidemiological studies in ambulatory settings have documented C. difficile infection in both adults and children who lack the usual risk factors of prior antibiotic use or hospitalization.
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Patients with diabetes mellitus (DM) are at increased risk of developing acute coronary syndromes (ACS). Furthermore, after hospitalization with ACS, patients with DM are at increased risk of suffering repeat hospitalization for ACS.
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The recently published IST-3 trial has stimulated great interest in the expanded use of intravenous thrombolysis (IV rtPA). Wardlaw and colleagues assessed all of the evidence from published randomized trials for IV rtPA in acute ischemic stroke using a meta-analysis.
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Side effects of finasteride; new ruling on pharmaceutical companies paying generic manufacturers; and FDA actions.
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After results of the pivotal NINDS intravenous thrombolysis (IV rtPA) trial were published in 1995, there has been a gradual extension of the time window from 3 hours to 4.5 hours, based on additional trials (ECASS II and III).