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Methylation of 16S ribosomal RNA (rRNA) has emerged as an important mechanism of resistance to aminoglycosides in pathogens including Enterobacteriaceae and non-fermenters including Pseudomonas aeruginosa and Acinetobacter species.
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In this paper, Hart and colleagues report the results of a meta-analysis of antithrombotic therapy in patients with nonvalvular atrial fibrillation (NVAF).
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In this retrospective study of C. difficile colitis due to a hypervirulent strain, 53% of 165 patients died.
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In this randomized pilot study, preoperative coronary revascularization in high-risk patients was not associated with an improved outcome.
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Statin-treated patients who developed symptoms of myopathy should be treated with at least 100 mg daily of coenzyme Q10 for a minimum of 30 days (assuming CPK values and/or other liver function tests are not abnormal) before discontinuing statin therapy.
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Stroke prevention among elderly patients with atrial fibrillation remains a challenging and pressing health concern.
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In patients with suspected pulmonary tuberculosis who are unable to expectorate sputum, culture of 3 induced sputum samples, all collected on the same day, is an effective and efficient means of diagnosis.
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The new guidelines recommend antibiotic prophylaxis of infective endocarditis in a much more restricted group of patients than did previous guidelines.
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This multicenter, randomized, double-blind, placebo-controlled trial finds that early initiation of low-dose, prolonged glucocorticosteroid therapy for ARDS results in improved lung injury scores and a greater likelihood of successful extubation by day 7.
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A meta-analysis of 18 studies that have examined the usefulness of procalcitonin measurement in the diagnosis of sepsis finds that the diagnostic performance of this measurement is low and that the test cannot reliably distinguish sepsis from other causes of the systemic inflammatory response syndrome.
