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In a multicenter study, critically ill patients with initial hyperlactatemia had improved outcomes (including shorter ICU stays and lower adjusted mortality) compared to control patients when they were managed for the first 8 hours with a resuscitation protocol targeted at reducing the lactate level by at least 20% every 2 hours.
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The relationship between blood pressure and cardiovascular events remains controversial, especially in patients with coronary artery disease who may need increased pressures to have adequate myocardial perfusion.
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Gastrointestinal (GI) bleeding is a major complication of dual anti-platelet therapy (DAPT) with aspirin and clopidogrel.
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Using a quality improvement (QI) process, ICU delirium, physical rehabilitation, and functional mobility were significantly improved and associated with a decreased length of stay.
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Outpatients with uncomplicated seasonal influenza were treated with single doses of IV peramivir 300 mg/kg, 600 mg/kg, or placebo. Peramivir significantly reduced the time to alleviation of symptoms at both doses compared with placebo. Peramivir was well-tolerated, and side effects were comparable to placebo.
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Central line-associated infections, particularly bloodstream infections (BSI), remain a huge issue in our technological age.
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Clinicians who send samples to the 95% of U.S. laboratories that test for Clostridium difficile infection using an enzyme-immunoassay (EIA) for toxins A and B are often frustrated by a negative laboratory result that doesn't fit their clinical impression or their olfactory suspicions.
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Acetaminophen (known as paracetamol outside the United States) is the most commonly used analgesic in the world, usually considered to be safe and benign.
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Each year in the United States, a few isolated cases of plague are reported. This year, possibly because of increased spring rains leading to an increase in the rodent population, an unprecedented 13 cases of plagues have occurred in 4 states already.
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The administration of supplemental oxygen to laboring patients with nonreassuring fetal heart rate patterns increases fetal oxygen saturation substantially and significantly. Fetuses with the lowest initial oxygen saturations appear to increase the most.