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In this prospective observational study, Kollef and associates enrolled patients with ventilator-associated pneumonia (VAP) in 20 ICUs across the United States in order to characterize the patients and the antimicrobial regimens used in treating them, as well as their mortality and lengths of stay.
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In the early 2000s, substantial evidenced-based interventions were added to the care of critically ill patients that significantly reduced mortalityincluding low tidal volume ventilatory support for acute respiratory distress syndrome (ARDS), protocolized sedation with daily awakening, Drotrecogin-alpha for severe sepsis, tight glycemic control, corticosteroids for refractory septic shock and preventative strategies for ventilator associated pneumonia.
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TNF Blockers: Should You Be Concerned?; FDA Actions
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Transfers of care can be problematic if critical information is not shared when responsibility transitions between clinicians. Although such "hand-offs" create the opportunity for error, transfer management in United States hospitals has never been described on a national level.
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The SPARCL study showed that 80 mg per day of atorvastatin reduced the overall incidence of recurrent stroke, and a meta-analysis of several large studies of ACE inhibitors showed a reduction in all stroke types, as well as a reduction in overall cardiovascular mortality.
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A medical research unit in the United Kingdom analyzed 18 different strategies for managing patients with suspected DVT.
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Both nitazoxanide and the investigational anionic polymer, tolevamer, may have efficacy comparable to that of standard therapies in the treatment of CDAD. The addition of rifampin to metronidazole is not superior to treatment with metronidazole alone.
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Aspiration of oropharyngeal secretions is considered one of the mechanisms of development of VAP. In this randomized trial of two oral decontamination medications, the authors show a significant reduction in the incidence of VAP.
