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Endotracheal intubation is a procedure fraught with multiple, potentially life-threatening complications.
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In this issue: Examining the three arms of the ACCORD trial; and FDA Actions: clopidogrel, dexlansoprazole, and tamsulosin.
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This clinical study was carried out to test the hypothesis that acetazolamide (Diamox®) would correct metabolic alkalosis and facilitate weaning in intubated patients with severe chronic obstructive pulmonary disease (COPD) who had elevated serum bicarbonate and were alkalemic.
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Endotracheal tubes (ETTs) coated with antimicrobial substances can reduce bacterial adhesion on the tube, block biofilm formation, and reduce bacterial burden in tracheal secretions. Various antimicrobial agents have been employed for this purpose.
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FDA is reviewing safety of TZDs; SSRI use with tamoxifen; Metformin smells like fish; FDA Actions.
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Even if asymptomatic, early elective aortic valve replacement should be considered for increasingly symptomatic patients with severe aortic valve stenosis because they have a poor prognosis with a high event rate and a risk of rapid functional deterioration, especially if the peak aortic jet velocity is above 5.5 m/sec.
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In this prospective, multicenter, randomized trial, addition of a helium-oxygen gas mixture to non-invasive positive pressure ventilation in the treatment of COPD exacerbations did not decrease the need for intubation when compared to non-invasive positive pressure ventilation alone.
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In this prospective, randomized, placebo-controlled trial from the Netherlands, 6,771 patients were screened on admission to the hospital for the presence of Staphylococcus aureus nasal colonization using real-time PCR.