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The development of an isolated supraclavicular node recurrence of breast cancer after primary surgical resection (including axillary node dissection) was found, upon review of the tumor registries of 8 community hospitals in The Netherlands, to occur very uncommonly (less than 1%). Examination of clinical outcomes for these patients indicates that isolated supraclavicular recurrence is an antecedent of disseminated disease, in that, even with local control (as achieved by radiation therapy), the great majority of patients soon develop systemic disease.
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Women who survive breast cancer may be at a lower risk of developing coronary artery disease compared with women without a history of breast cancer.
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There has been some controversy on the role of taxanes in combination with platinum for the treatment of ovarian cancer. In the current report, patients who relapsed after a disease-free interval of 6 months or more were randomized in 2 large, multicenter trials conducted in Europe to receive either platinum (or typical platinum-based regimens) or paclitaxel plus platinum.
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Prolapse occurs along a spectrum from early and asymptomatic to advanced and symptomatic. The authors define anatomic cutoffs that are likely to result in symptomatic and clinically significant prolapse.
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Barriers to guideline-adherent care for advanced ovarian cancer are impacted by geographic proximity to a high-volume hospital and travel distance. However, these geographic barriers disproportionately affect racial minorities and women of lower socioeconomic status.
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In this prospective cohort study of 161 nulligravid women, there was no reliable threshold of uterine length or flexion angle measurements that were predictive of painful or difficult insertions. History of severe dysmenorrhea was the only predictor of insertion pain.
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News from the KEEPS Study: HRT Does Not Decrease Progression of Atherosclerosis Over 4 Years of Treatment
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This study completes the Imazio et al trilogy on the treatment of pericarditis and suggests that colchicine is the drug of first choice for acute pericarditis, first recurrences, and multiple recurrences.
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This observational cohort study found that reduced ICU bed availability is associated with increased rates of ICU readmission as well as ward cardiac arrest if medical ICU beds were on shortage.
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In this retrospective study of extubation outcomes in five ICUs at a single medical center, patients extubated at night had no increase in adverse events and their mortality rates and lengths of ICU stay were lower. However, these results were likely affected by the high proportion of post-cardiac-surgery patients in the nighttime extubation group.