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A proposed guideline by the Centers for Disease Control and Prevention on hospital antimicrobial stewardship programs includes the following key aspects, as outlined recently in Atlanta at a meeting of the CDC Healthcare Infection Control Practices Advisory Committee.
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Threat of untreatable infections could prompt regulatory action
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There comes a time in infection control when there are enough epidemiological indicators and sufficient risk of patient harm that one must take decisive action, a la public health pioneer John Snow removing the Broad Street water pump handle to end a legendary cholera outbreak in 19th century London.
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Relative to the general population, the risk of anal cancer in HIV-infected patients remains very high. Unlike other malignancies associated with AIDS, effective antiretroviral treatment appears to have no preventive effect on anal cancer, particularly among men who have sex with men.
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Two recent reports provide supportive evidence for current strategies in the management of prostate cancer. The first, from Finland, is a report of the marginal value of PSA screening in terms of long-term prostate cancer survival. And, from a cooperative observational cohort in the United States, there is suggestive evidence that radical prostatectomy provides a somewhat more favorable survival outcome when compared to external beam radiotherapy.
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Ninety-six women with breast cancer undergoing radiotherapy during a 5- to 6-week interval were randomized to either a qigong group or a wait-list control group. The results indicate that the women in the qigong group had clinically significantly less depressive symptoms and better quality of life than the control group.
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In a single-arm, multicenter, Phase 2 trial, bevacizumab in combination with docetaxel and carboplatin achieved a pathological complete response in 19 of 45 patients with stage II/III triple-negative breast cancer. Forty-four of the 45 patients completed the planned six cycles and toxicity was manageable. One patient had delayed wound healing as a subsequent surgical complication. Thus, bevacizumab may provide significant improvement in neoadjuvant strategies for triple-negative breast cancer and further investigation is warranted.