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FDA issues multiple drug safety alerts; ARBs and cancer risk; and FDA actions.
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In a trial of two platinum-based chemotherapy regimens for non-small-cell lung cancer in older patients, pretreatment assessment of physical function and quality of life predicted certain different adverse outcomes but neither treatment assignment was superior to the other with regard to improved "global" quality of life.
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In recent months, Escherichia coli O104:H4 has infected more than 4,000 people and caused 880 cases of hemolytic uremic syndrome (HUS) in Europe, with the majority of cases reported in Germany and with more recent outbreaks in France and Switzerland. Travelers should implement food hygiene precautions to prevent infection when visiting Europe.
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Using an algorithm based on score and chest X-ray when appropriate, the overall sensitivity for the detection of aortic dissection was 96%.
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This randomized study of low-tidal-volume ventilation during and after cardiac surgery, in comparison to ventilation with tidal volumes of 10 mL/kg predicted body weight, showed no differences in median ventilation time but higher rates of extubation by 6 and 8 hours postoperatively and fewer reintubations in the low-tidal-volume group.
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Standard therapy for bacterial meningitis in children is probably overkill but it is risky to cut back in resource-rich countries.
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Most (83%) patients/surrogates stated they preferred full code status but only 4% could identify the components of CPR; 16% stated preferences that differed with the medical record.
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The benefits of cardiac rehabilitation following myocardial infarction (MI) are well known. However, whether these benefits are also seen in ambulant community-based patients who undergo percutaneous coronary intervention (PCI) is not known.
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Previous studies have shown that the use of a multi-part daily rounding checklist reduces errors of omission in the ICU such as failure to discontinue empirically started antibiotics, to perform spontaneous breathing trials to see whether ventilated patients can be weaned and extubated, or to provide prophylaxis against deep venous thrombosis (DVT).
