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In a nationally representative sample of U.S. hospitals, reported routine use of daily interruption of sedation for mechanically ventilated patients was associated with the presence of a leadership emphasis on safety culture, receptivity of the staff to practice change, and participation in a collaborative to prevent health care-associated infections. There was no association with the number of hospital beds or with the presence of a medical school affiliation.
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Based on the findings of this meta-analysis of seven randomized controlled trials, early (7 days after intubation) or late (any time after 7 days) tracheostomy placement did not alter clinical outcomes in study patients, including no differences in mortality, incidence of ventilator-associated pneumonia, duration of mechanical ventilation, ICU stay, hospital stay, or sedation.
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In a retrospective chart review at a single university urogynecology practice between 2000 and 2009, the authors identified 197 patients who underwent posterior tibial nerve stimulation (PTNS) after failing medical therapy for overactive bladder (OAB) with anticholinergic medication.
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The Cancer Genome Atlas research network (TCGA) is an open-sourced multi-institutional collaborative charged by the National Cancer Institute (NCI) and the National Human Genome Research Institute effort to explore the molecular aberrations of cancer to better understand the disease and identify new treatment approaches.
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In the initial phase of data collection, the authors identified two vaginal cuff dehiscences out of 665 total laparoscopic hysterectomies with transvaginal cuff closure (0.3%).
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Hot flashes occur as a common consequence of breast cancer therapy and are quite debilitating for some.
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The investigators performed a pooled analysis of individual data from two large studies by the International Agency for Research on Cancer (IARC) and Institut Català d'Oncologia (ICO) research program on human papillomavirus (HPV) and cervical cancer.
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Dealing with cytomegalovirus (CMV) can be vexing for everybody involved, but a recent paper may help with the management and counseling of patients infected with this virus at different times before and during pregnancy. Feldman et al studied 580 pregnant patients who were diagnosed with seriologic evidence of CMV infection.
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In this issue: New indication for rivaroxaban; new study on warfarin testing; medications causing adverse drug events; niacin as an add-on therapy; and FDA actions.
