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Self-reported personal history of endometriosis was associated with an increased risk of ovarian cancer. Further, it was differentially associated with clear cell, endometrioid, and low-grade serous ovarian carcinoma in this pooled analysis. No relationship appeared between endometriosis and high-grade serous or mucinous ovarian cancer, or borderline variants of these two histologies. The results suggest further work is necessary to understand whether endometriosis plays a strategic precursor role in certain ovarian cancer histological subtypes.
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A middle-aged man with community-acquired pneumonia complicated by underlying cardiomyopathy develops the acute respiratory distress syndrome (ARDS).
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In the ICU at the University of Connecticut Health Center, adult patients with both medical and surgical problems are primarily managed by the same team of intensivists.
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The purpose of this article was to provide a systematic review and critical appraisal of the literature on the incidence and risk factors for unplanned endotracheal extubations, factors associated with reintubations, and outcomes of unplanned extubations. Several evidence-based recommendations were presented to prevent unplanned extubations.
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This systematic review and meta-analysis reviewed studies evaluating the implementation of multidisciplinary tracheostomy teams in acute care hospitals.
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In a retrospective review of 267 patients evaluated at M.D. Anderson Cancer Center with apparent early-stage, node-negative breast cancer, 15% were found to harbor "occult" metastases upon more intensive scrutiny of the axillary node specimens. In this series, long-term follow-up indicates that such discovery was not associated with a greater frequency of recurrence or poorer survival.
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In a small, single-institutional, prospective, randomized, placebo-controlled trial, 14 eligible patients (median age 47 years) with clinical and radiographic evidence of radiation necrosis secondary to prior head-and-neck or CNS irradiation were randomized to receive intravenous saline of bevacizumab at 3-week intervals. Patients were followed with serial MRI scans, neurologic examinations, and formal neuropsychological examinations.