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The pandemic influenza plan recently unveiled by the Department of Health and Human Services specifies four major components of preparedness and response to pandemic influenza:
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The virulence of the 1918 pandemic strain was so extraordinary that there are accounts of people who felt well in the morning but were dead by nightfall.
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If avian H5N1 influenza emerges as a pandemic strain, no currently available vaccine will be completely protective. Therefore, the thrust of the nations pandemic influenza plan is aimed at rapidly producing vaccine and stockpiling effective antivirals.
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Based on ongoing research with the resurrected 1918 H1N1 pandemic virus, it appears that avian influenza H5N1 bird flu could rapidly adapt and spread through the human population with a few genetic changes that allow a transmission tipping point.
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The purpose of this meta-analysis was to assess the efficacy of subglottic secretion drainage in preventing ventilator-associated pneumonia (VAP). Dezfulian and colleagues performed a comprehensive analysis of randomized trials that have compared subglottic secretion drainage with a standard endotracheal tube care in mechanically ventilated patients.
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This observational study from a university-affiliated, urban, tertiary hospital in Toledo, OH, retrospectively reviewed the records of 840 patients admitted to various ICUs to determine if the time to first visit by a physician had an effect on a number of clinically relevant outcomes.
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Care of the critically ill pregnant patient poses unique challenges. The normal physiology of a pregnant patient differs considerably from that of a non-pregnant patient and these differences may affect many aspects of routine care: resuscitation, mechanical ventilation, choice of drugs and use of diagnostic studies are some examples.
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