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Imatinib inhibits the BCR/ABL tyrosine kinase in CML, leading to improved responses over standard therapy. This report provides 5 year follow-up from the seminal IRIS study of upfront imatinib for chronic phase CML among the 553 patients randomized to 400 mg of imatinib.
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Drug Labels A Prescription for Misunderstanding?; Osteonecrosis of the Jaw New Side-Effect to Bisphosphate Use; Beta-Blockers and Depression Unlinked?; FDA Actions
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West Nile Virus (WNV) infection is a growing epidemic that impacts more persons and more aspects of our health care system yearly. A significant percentage of affected patients require admission to and care in an intensive care unit (ICU).
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Borges and colleagues in Sao Palo, Brazil, studied 26 patients with acute lung injury or the acute respiratory distress syndrome (ARDS) to determine whether atelectatic lung areas could be fully recruited and oxygenation improved using a protocol employing progressively higher levels of positive end-expiratory pressure (PEEP).
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This study reports findings from a sample of 393 nurses who completed a daily log book for 28 days by recording information about work hours, sleep/wake patterns, perceptions of fatigue and stress, and errors or near errors during work shifts.
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Segers and colleagues of the University of Amsterdam conducted this randomized, double-blind clinical trial at a 480-bed community hospital that performs 1200 cardiac surgical procedures annually.
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The lead paper in the November issue of Obstetrics and Gynecology should stimulate lively discussion regarding the counseling of patients of advanced maternal age (AMA), and, if taken at face value, could impact the field of prenatal diagnosis, in general.
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The resection of tumor nodules (or cytoreduction) before primary chemotherapy has been linked closely with survival in patients with advanced epithelial ovarian cancer. Chi and colleagues set out to evaluate the merits of cytoreduction completeness in a homogeneous cohort of ovarian cancer patients with bulky metastatic disease.