Head Trauma
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Role of Neurologists and Diagnostic Tests in the Management of DSP
Synopsis: Using the clinical history and simple, inexpensive laboratory tests, community-based outpatient neurologists were able to determine the cause of distal symmetric polyneuropathy in three-fourths of patients presenting with typical symptoms. -
Chemotherapy-Induced Neuropathy in Pediatrics
Synopsis: Chemotherapy-induced peripheral neuropathy is common in children treated for a variety of cancers, but the long-term prognosis for recovery is excellent. -
To Sleep, Perchance to Clear Our Beta-Amyloid
SYNOPSIS: Both animal studies and human data suggest that A-beta 42 amyloid is cleared from the brain during sleep, and that sleep deprivation may be a risk factor for the development of Alzheimer’s disease.
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New Diagnostic Methods for Creutzfeldt-Jakob Disease
Synopsis: Novel noninvasive diagnostic tests for Creutzfeldt-Jakob disease (CJD; nasal brushings) and variant CJD (urinary prion proteins) are reported to be highly sensitive and specific in two recent studies.
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Will New Approaches Help to Treat ALS?
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Pharmacology Watch: High-Dose Rofecoxib Confirmed Prothrombotic, Study Shows
Debate over the cardiovascular effects of COX-2 inhibitors has raged for more than a year since a special communication was published in JAMA last August suggesting an increase in cardiovascular events with rofecoxib (Vioxx). Now a large retrospect, the cohort study from the Tennessee Medicaid program seems to confirm the prothrombotic effects of rofecoxib, at least in high dose. -
Pharmacology Watch: Forgot Your Ginkgo? Forget About It, Study Shows
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Antipsychotics in Alzheimer's Patients: The CATIE-AD Study
Because of adverse effects, special care should be used when prescribing the atypical antipsychotic drugs for patients with dementia. -
Rolandic Epilepsy Surgery — Weighing the Risks
Surgery for epilepsy in and around sensory-motor cortex can be effective in controlling seizures, but mild post-operative neurological deficits are not uncommon in patients operated on after age 25. -
What is the Mechanism of Transient Global Amnesia?
Patients show reversible MRI signal abnormalities in the CA-1 sector of the hippocampal cornu ammonis early in the course of TGA. They are not correlated with any specific clinical or memory features of the episode.