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This study examines and describes the occurrence of an inverse neurovascular coupling response in peri-contusional brain tissue as a potential and novel mechanism for secondary brain injury.
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In addition to autoantibodies directed against the acetylcholine receptor (AchR) and the receptor-associated protein muscle-specific tyrosine kinase (MuSK) patients with myasthenia gravis (MG) demonstrate a host of other antibodies.
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Carotid MRI scanning was performed in 1414 stroke-free participants, older than the age of 45 years, to assess the morphology of any atherosclerotic plaques, specifically to look at the presence of a lipid core, intraplaque hemorrhage, calcification, or fibrous tissue in each carotid artery.
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DaTSCAN imaging makes use of the dopamine transporter (DAT) ligand [123I]FP-CIT used with SPECT to provide a means to visualize the integrity of the nigrostriatal dopaminergic system. DaTSCAN has been approved in the United States to aid in evaluation of patients in whom Parkinsons disease (PD) and certain other related neurodegenerative disorders are suspected.
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Natalizumab is a monoclonal antibody that is FDA-approved for the treatment of relapsing-remitting multiple sclerosis (MS). Among the available options to treat MS, it is one of the most effective.
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In a Phase 2 trial, antibodies to calcitonin gene-related peptide resulted in a significant decrease in migraine days measured from baseline to weeks 5 to 8 after one intravenous infusion of the medication, as compared to a placebo infusion. But the high-rate of placebo response (50%) warrants caution in the interpretation of the study results and requires more investigation.
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An index of Neurology Alert articles organized by topic.
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Synopsis: Traditional comprehensive neuropsychological testing has greater reliability, sensitivity, and specificity than bedside screening tests in the accurate diagnosis of mild cognitive impairment.
