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Uterine (papillary) serous cancer is a genomically unstable cancer associated with poor survival even in stage i. it is also frequently associated with a secondary malignancy, particularly breast cancer. Comprehensive surgical staging is recommended since extrauterine disease can be present without other high-risk uterine features, like myometrial invasion. However, an optimal adjuvant treatment protocol remains to be defined.
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This retrospective cohort study of 12,500 women with breast cancer, treated in the community, compared the incidence of congestive heart failure in those who received trastuzumab-containing adjuvant chemotherapy regimens with those who did not. There was a four-fold increase in the risk of heart failure in women who received trastuzumab alone and a seven-fold increase in those who received anthracycline plus trastuzumab.
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By examining a large series of patients who had PET/CT scans obtained within 2 months of diagnosis of metastatic breast cancer, it was discovered that site-specific SUV correlated with survival. This was most apparent and statistically significant when comparing survival for patients with bone metastases, although similar but not statistically significant data also were presented for patients with liver, lung, or lymph node involvement.
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The emergence of maternal DNA testing for fetal an-euploidies has necessitated a rethinking of our standard screening protocols. With reasonable accuracy, a single blood test can now rule out fetal trisomy 21, 18, and 13, in addition to sex chromosome abnormalities such as Turner syndrome.
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Between September 1, 1987, and January 31, 2001, a total of 4047 obese persons were enrolled in the Swedish Obesity Study (SOS) intervention trial.
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Mediators of the autonomic response to stress, such as the catecholamines norepinephrine and epinephrine, promote cancer growth, metastasis, and progression in preclinical models.
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Although the incidence of hysterectomy has declined in recent years, it remains the most common major gynecologic procedure, and many women are offered or consider elective bilateral oophorectomy (BSO) at the time of hysterectomy to reduce ovarian cancer risk.
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In this issue: Dementia and benzodiazepines; effectiveness of omega-3 fatty acid and Ginkgo biloba supplements; and FDA actions.
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Response rates for patients with hairy cell leukemia are high and typically of long duration, yet one-third or more will relapse. The use of oral fludarabine in combination with rituximab in four monthly cycles was shown to be highly effective in reinducing durable remissions.