-
In this Phase 2 trial, 11 patients with relapsed/refractory primary central nervous system lymphoma after high-dose, methotrexate-based regimen were treated with pemetrexed 900 mg/m2 every 3 weeks, dexamethasone 4 mg bid, folate, and B12 supplementation. The treatment had an overall response rate of 55%, disease control rate of 91%, median progression free survival of 5.7 months, and median overall survival of 10.1 months. Toxicities were more than expected with the standard pemetrexed dose (500 mg/m2) and were primarily hematologic and infectious, which were easily managed. Although single-agent activity of pemetrexed in this study is novel and promising, optimal dosing and efficacy need to be studied further.
-
-
Findings of a small study indicate that Shang Ring, a device in development, is safe and acceptable to men, which might aid in increasing access to voluntary adult male circumcision in areas at high risk of HIV.
-
New research indicates that use of magnetic resonance imaging (MRI) is safe for use in women who rely on such contraceptive methods as intrauterine devices (IUDs) and implants, as well as in women who have tubal microimplants inserted during hysteroscopic sterilization.
-
In June 2012, the Centers for Disease Control and Prevention (CDC) released the U.S. Youth Risk Behavior Surveillance Summary (YRBS) for 2011.1 In the first paragraph, say the most significant finding from the report.
-
The Food and Drug Administration (FDA) has cleared the OraQuick In-Home HIV Test for sale directly to consumers, which makes it the first and only rapid over-the-counter (OTC) HIV test approved in the United States.
-
Your neighborhood pharmacy now offers checks for high blood pressure, cholesterol levels, and diabetes; testing for HIV might be the next addition in service.
-
Listen to the online presentation of "It's Not Just the Pathogen Anymore: The Genital Microbiome and Implications for Sexually Transmitted Infections," the latest in the quarterly STD Prevention Science Series 2012 co-sponsored by the Division of STD Prevention of the Centers for Disease Control and Prevention and the American Sexually Transmitted Diseases Association.
-
Be sure to screen all women between the ages of 14 and 46 for intimate partner violence (IPV), advises new research.
-
Add new information to your contraceptive counseling databank: Findings from a just-published study indicate the absolute risk of increased thrombotic stroke and myocardial infarction (MI) associated with the use of hormonal contraception is low, although the relative risks vary depending on whether higher doses of estrogen are used.
