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Poly(adenosine diphosphate [adp]-ribose) polymerase (PARP) is an enzyme participating in low-fidelity DNA repair of single strand breaks. Pharmacologic inhibition of PARP has shown to be effective in tumors lacking homologous recombination, such as those harboring silencing mutations of BRCA1 and 2.
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To provide guidance to clinicians on the use of hormone replacement therapy, the authors conducted a systematic review of the randomized, placebo-controlled trials of menopausal hormone therapy published in English since 2002 that assessed primary prevention of chronic conditions.
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The World Health Organization (WHO) has reaffirmed its guidance that women living with HIV or at high risk of HIV infection can safely use all hormonal contraceptives without restriction following a recent review of links between the contraceptives and HIV acquisition.
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Reaching young people with an HIV prevention message is important: The Centers for Disease Control and Prevention (CDC) estimates young people ages 13-29 accounted for 39% of all new HIV infections in 2009.
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With relatively few contraindications to use, progestin-only pills might be a possible candidate for over-the-counter (OTC) use in the United States. But what will it take to move progestin-only pills to the drugstore shelves?
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Clinicians and researchers now have more comprehensive parameters to assess the stages of menopause with updated criteria known as the Stages of Reproductive Aging Workshop +10 (STRAW +10).
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African-American women at risk for HIV are the focus of a new prevention program launched by the Centers for Disease Control and Prevention (CDC). "Take Charge. Take the Test" is running in 10 cities where such women are especially hard-hit by the disease.
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Another oral contraceptive (OC) packaging alert has been issued. Check your clinic's stock for norgestimate and ethinyl estradiol birth control pills distributed by Glenmark Generics.
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Public health officials are sounding the alarm on the growing threat of multi-drug resistant gonorrhea. What will it take to turn the tide against gonorrhea, the second most commonly reported communicable disease in the United States?
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The next patient is a 16-year-old young mother who became pregnant at 14 when the condom broke during intercourse and no emergency contraception was used after the method failure.
