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Myelodysplastic syndromes (MDS) usually occur in older adults and, as such, comorbid conditions are common. The investigators found that among 418 MDS patients, at least one comorbid condition existed in 93% at diagnosis. Comorbidity scores were generated using three common scoring systems: the HCT-CI, MDS-CI, and CCI. Worse survival was linked to higher CCI (p = 0.01) and MDS-CI (p = 0.02) but not HCT-CI. Higher CCI scores were associated with non-leukemic death and progression of red blood cell dependency, whereas higher comorbidity by HCT-CI and MDS-CI did not. Higher comorbid burden by CCI in MDS predicts for worse survival and non-leukemic death. Comorbidity data may help refine prognosis for MDS patients.
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Uric acid as a weak organic acid (pka 5.8) is poorly soluble at physiological pH.
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A 84-year-old retired professor was referred for second opinion regarding management of prostate cancer. He had been relatively healthy, with a history of hyperlipidemia and gout.
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While it is not in the top tier of contraceptive effectiveness, the diaphragm remains an option as a female-controlled method of birth control. What do you know about this form of family planning?
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What is your practice when it comes to screening women for chlamydia? The Centers for Disease Control and Prevention (CDC) recommends annual chlamydia screening for all sexually active young women age 25 and younger.
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Your next patient is a young woman who was in two months ago for a chlamydia infection. You provided her with a prescription and asked that she have her partner come in for evaluation, testing, and treatment.
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While the human papillomavirus (HPV) vaccine has been approved for use in men, how many are open to receiving it? New research indicates men might be more willing to receive vaccination when they learn the vaccine can prevent cancer.
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Findings from a new national report reflect an increase in the use of early medication abortion.
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Many women might choose the contraceptive injection depot medroxyprogesterone acetate (DMPA, Depo-Provera) for its ease of use, but they might discontinue the method due to irregular bleeding.