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Among three distinct cohorts of lung cancer patients and matched controls (without tumor), the authors present data on the capacity for an assay that detects antibody to tumor-associated antigens to discriminate those with lung cancer and those without. Using a panel of six antigens, they found their assay to have sensitivity/specificity of approximately 40%/90%. If confirmed in an independent prospective study, such screening may be a very effective adjunct to imaging studies in the early recognition of lung cancer.
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The optimal standard salvage therapy for relapsed or refractory AML remains undetermined. The authors retrospectively compared two regimens at a single institution: CLAG (cladribine, high-dose cytarabine, and G-CSF) with MEC (mitoxantrone, etoposide, and cytarabine). These observational data without adjustment suggest CLAG may be superior to MEC. Nevertheless, outcomes for relapsed or refractory AML remain poor and clinical trials should be entertained when available.
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Apixaban and rivaroxaban near approval for nonvalvular atrial fibrillation; fidaxomicin for C. difficile infections; guideline for intensive insulin therapy; and FDA Actions.
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HPV infection is a major cause of morbidity in both genders. HPV vaccination (both bivalent and quadrivalent) has proved effective in girls and women, including those outside of the original age indications and those with prior sexual activity. Much less is known of vaccine efficacy in boys and men for the prevention of HPV-associated diseases.
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In this issue: Apixaban and rivaroxaban near approval for nonvalvular atrial fibrillation; fidaxomicin for C. difficile infections; guideline for intensive insulin therapy; and FDA Actions.
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After two pretreatment cycles, 196 patients with menorrhagia were randomized to tranexamic acid or placebo.
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Outcome data from 52,218 u.s. participants in the international Active Surveillance of Women Taking Oral Contraceptives (INAS) study were used to analyze contraceptive failure in association with typical use of oral contraceptive (OC) pills.
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It has been shown that delayed cord clamping after delivery will increase the blood volume of term and preterm neonates without any apparent downside complications, except for an inability to administer resuscitation to those who need it immediately.
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A 25-year-old G3P1021 presents to clinic concerned that her intrauterine device (IUD) strings feel longer.
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