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In a prospective analysis, healthy women known to be carriers of BRCA1 or BRCA2 mutations chose either bilateral mastectomy or active surveillance. Ascribing to careful methodological detail, the investigators found that those who chose surgery had lower risk for breast cancer occurrence and better survival. Nonetheless, the authors note that longer follow-up and a larger sample size are needed to confirm statistical significance of their observations.
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Imatinib therapy was discontinued in 40 patients who had sustained undetectable BCR-ABL transcripts for 2 or more years, and close follow-up revealed approximately 50% remained with undetectable disease off treatment at 24 months.
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Women undergoing pediatric cancer care are significantly more likely than their siblings to have clinical infertility (≥ 12 months of non-conception despite desired attempts) and total infertility (clinically infertile women who also reported ovarian failure defined as never initiating menstruation or no periods 5 years before baseline questionnaire).
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In this Phase 2, single-arm, multicenter clinical trial conducted in the Netherlands, 50 patients with metastatic rectal cancer were treated with 5 days of 5 Gy RT followed by six cycles of intravenous bevacizumab (7.5 mg/kg) and oxaliplatin (130 mg/m2) on D1 and capecitabine (1000 mg/m2) orally on D1-D14.
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A new Agency for Healthcare Research and Quality (AHRQ) review of available evidence reveals that women who have problematic irregular or heavy cyclic menstrual bleeding have several safe and effective nonsurgical treatment options.1
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In a decision more than 10 years in the making, a U.S. Federal District judge ruled April 5, 2013, that the Food and Drug Administration (FDA) must lift age and point-of-sale restrictions on Plan B One-Step emergency contraception (EC) within 30 days.
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Results of a just-published study indicate a possible method to predict when a woman will have her final menstrual period.1 Such findings might be helpful in aiding women and providers in combatting potential bone loss and cardiovascular risk associated with onset of menopause.
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Women over age 40 might underestimate their need for effective birth control; however, despite declining fertility, such women can be at risk for unintended pregnancy.
