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Checklists and clear protocols for clinical care have been highly successful in infection prevention and other fields, but can be easily undercut by a simple non-action: silence.
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The broad misconception that infectious diseases were fading as a medical concern with the development of antibiotics and vaccines was dashed in dramatic and tragic fashion in 1981 when the first cases of a strange new illness were reported among groups of gay men in New York, Los Angeles and San Francisco. The AIDS epidemic had begun.
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A randomized, double-blind, placebo-controlled clinical trial was conducted from December 2009 through January 2011 at 18 feeding sites in Malawi. This region of oral sub-Saharan Africa has a subsistence farming population with an estimated 11% of adults infected with the human immunodeficiency virus (HIV).
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Despite notable advances in critical care medicine, mortality from severe sepsis remains unacceptably high. With current therapeutic strategies, nothing has proven more crucial than early and effective antibiotics.
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Human metapneumovirus (HMPV) was only discovered about a decade ago and until this study the extent of the disease — particularly in the young — was not known.
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Doernberg and colleagues sought to determine whether receipt of doxycycline was associated with protection from development of Clostridium difficile infection (CDI) in hospitalized patients being treated with ceftriaxone, a known high-risk antibiotic for CDI.
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Gane et al conducted a randomized open label trial of 40 patients with HCV genotype 2 or 3 infection which evaluated sofosbuvir 400 mg once daily plus ribavirin (RBV) for 12 weeks.
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Saint S, et al, Perceived strength of evidence supporting best practices to prevent health care-associated infection: results from a national survey of infection prevention personnel. Am J Infect Control 2013;(41):100-106.
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In this issue: Aspirin use and AMD risk; using NSAIDs and antihypertensive agents; and FDA actions.
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