For only the second time since 2005, the Director General of the WHO, under the authority of the International Health Regulations Act, has issued a directive for those traveling to or from countries endemic for polio, in order to stem the recent and somewhat alarming spread of disease.
Measles was declared to have been eliminated in the U.S. in 2000. However, the infection is endemic in 5 of the 6 World Health Organization regions of the world and causes an estimated 20 million cases in the world each year.
The USPHS has provided an extensive document describing their recommendations for chemoprophylaxis of HIV infection in individuals with high levels of ongoing risk.
A large, multicenter clinical trial that compared protocol-based care to usual care for patients presenting to emergency departments with early sepsis and septic shock found no differences in clinical outcomes. However, early recognition and therapy was beneficial and should be the standard of care.
