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Of 696 episodes of community-acquired meningitis in adults identified by the nationwide Dutch Meningitis Cohort study from 1998 to 2002, 30 (4%) were due to Listeria monocytogenes. The mean age was 65 ± 18 years; all 10 of the previously immunocompetent patients were >50 years of age.
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The new quadrivalent Human Papillomavirus (HPV) L1 virus-like particle vaccine (types 6, 11, 16, 18) was studied for immunogenicity and reactogenicity in 506 girls and 510 boys (10-15 years of age) and 513 young women (16-23 years of age). Vaccine was administered in the standard schedule of 0, 2, and 6 months. Type-specific serologies were performed in a blinded fashion using a competitive Luminex xMAP-based immunoassay (cLIA) on serum samples obtained at 0, 3, and 7 months.
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Community-Associated MRSA (CA-MRSA) has emerged as an important cause of skin and soft-tissue infection. Most isolates of CA-MRSA are positive for the Panton-Valentine leukocidin (PVL), an exotoxin that is generally absent from "classic" hospital-associated MRSA strains. This suggests that PVL may be an important virulence determinant in CA-MRSA.
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The Non-nucleoside Reverse Transcriptase inhibitors (nnRTI's) including both efavirenz and nevirapine have intrinsic in vitro activity superior to all the other classes of antiretroviral agents. Clinical trials including patients who have been followed now for many years on efavirenz have demonstrated the durability, as well as potency, of these agents.
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Drug Labels A Prescription for Misunderstanding?; Beta-Blockers and Depression Unlinked?; FDA Actions
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A 56-year-old man, originally from india and with a history of hypertension, had developed bilateral red, swollen ankles while on a recent trip to Bangalore. Five days later, the patient developed severe fever and shaking chills that resolved within 48 hrs.
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Drug Labels A Prescription for Misunderstanding?; Osteonecrosis of the Jaw New Side-Effect to Bisphosphate Use; Beta-Blockers and Depression Unlinked?; FDA Actions
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In October of 2005, the first reports of 5 cases and the possible association of Guillain-Barré Syndrome (GBS) and recipients of Menactra® Meningococcal Conjugate Vaccine (MCV4) were reported.
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